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Related Experiment Videos

Mitral valve prolapse and autonomic function in panic disorder

T Hamada1, Y Koshino, T Misawa

  • 1Department of Clinical and Laboratory Medicine, Fukui Medical School, Matsuoka, Japan.

Acta Psychiatrica Scandinavica
|March 28, 1998
PubMed
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Mitral valve prolapse (MVP) is more common in panic disorder (PD) patients, especially those with depression. Autonomic function, specifically parasympathetic activity, is impaired in PD patients with MVP.

Area of Science:

  • Cardiology
  • Psychiatry
  • Autonomic Neuroscience

Background:

  • Panic disorder (PD) is a condition often associated with physical symptoms.
  • Autonomic dysfunction has been implicated in the pathophysiology of PD.
  • The relationship between mitral valve prolapse (MVP) and PD requires further investigation.

Purpose of the Study:

  • To investigate the prevalence of MVP in patients with PD.
  • To assess autonomic function, particularly parasympathetic activity, in PD patients.
  • To explore the association between MVP, autonomic function, and depression in PD.

Main Methods:

  • Electrocardiogram (ECG) analysis, including the coefficient of variation for R-R intervals (CV R-R), was used to assess autonomic function.
  • Patients diagnosed with PD were compared to healthy controls.

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  • Subgroup analysis was performed based on the presence of MVP and depression.

    • Main Results:

    • The incidence of MVP was higher in PD patients (32.2%) than in controls (16.7%), though not statistically significant.
    • MVP prevalence was significantly higher (58.1%) in PD patients with comorbid depression compared to those without (25.7%).
    • PD patients exhibited lower CV R-R values, indicating reduced parasympathetic activity, which was more pronounced in those with MVP and depression.

    Conclusions:

    • MVP may be associated with PD, particularly when depression is present.
    • Reduced parasympathetic nervous system activity, as indicated by lower CV R-R, is linked to PD and is further associated with MVP and depression.
    • These findings suggest a potential role for autonomic dysfunction in the interplay between MVP, PD, and depression.