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Antimicrobial activity of novel furanonaphthoquinone analogs
K Nagata1, K I Hirai, J Koyama
1Department of Bacteriology, Hyogo College of Medicine, Nishinomiya, Japan. kunagata@hyo-med.ac.jp
Antimicrobial Agents and Chemotherapy
|March 28, 1998
Abstract:
Analogs of furanonaphthoquinone (FNQ) from Tecoma ipe Mart had MICs ranging from 1.56 to 25 microg/ml against gram-positive bacteria. FNQ showed significantly lower MICs against methicillin-resistant Staphylococcus aureus than against methicillin-sensitive S. aureus. FNQ inhibited Helicobacter pylori with an MIC of 0.1 microg/ml. Fungi, including pathogenic species, were sensitive to FNQ with MICs similar to those of amphotericin B.