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Related Experiment Videos

A fluorocarbon emulsion with a high solubility for CO2

W H Matthews, J A Kylstra

    Undersea Biomedical Research
    |June 1, 1976
    PubMed
    Summary

    This study details the creation of a stable fluorocarbon-based emulsion using ultrasonic energy. The resulting emulsion exhibits specific physical properties and gas solubility characteristics, making it suitable for potential biomedical applications.

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    Area of Science:

    • Biomaterials Science
    • Chemical Engineering
    • Medical Physics

    Background:

    • Development of stable emulsions is crucial for various biomedical applications, including artificial blood substitutes.
    • Fluorocarbons offer unique properties like high gas solubility, but their emulsification can be challenging.

    Purpose of the Study:

    • To develop a stable emulsion using FC-80 fluorocarbon.
    • To characterize the physical and gas-carrying properties of the prepared emulsion.

    Main Methods:

    • A mixture of FC-80 fluorocarbon, 0.3-M THAM solution (pH 7.4), and F68 Pluronic surfactant was subjected to ultrasonic energy.
    • Physical properties including density, viscosity, and droplet size were measured.
    • Gas (O2 and CO2) content was determined at varying partial pressures.

    Main Results:

    • A stable emulsion was successfully prepared.
    • The emulsion demonstrated a density of 1.24 g/ml, absolute viscosity of 2.4 centipoise, and a fluorocarbon-droplet diameter of approximately 3 μm.
    • The emulsion exhibited predictable O2 and CO2 solubility characteristics.

    Conclusions:

    • Ultrasonic energy is an effective method for creating stable FC-80 fluorocarbon emulsions.
    • The characterized physical and gas solubility properties suggest potential utility in oxygen delivery applications.

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