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Fatty acid binding to rat liver fatty acid-binding protein is modulated by early glycolytic intermediates
J M Stewart1, V F Dewling, T G Wright
1Department of Biology and Biochemistry, Mount Allison University, Sackville, New Brunswick, Canada. jstewart@mta.ca
Biochimica Et Biophysica Acta
|May 9, 1998
Abstract:
Fatty acid binding to rat liver fatty acid binding protein in the presence of glycolytic metabolites and at different pH (optimal 7.2) and ionic strength was studied. Binding decreased logarithmically with ionic strength. Glucose and glucose-6-phosphate increased fatty acid binding significantly with K0.5 within physiological ranges while glucose-1-phosphate and phosphate ion caused no effect.