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Perivascular localization of nitric oxide synthase in the rat adenohypophysis: potential implications for function
C O Okere1, E Murata, T Higuchi
1Department of Physiology, Kochi Medical School, Nankoku, Kochi 783, Japan.
Brain Research
|May 2, 1998
Abstract:
The possible localization of nitric oxide (NO) synthase (NOS) in proximity to the microvasculature was examined in the rat adenohypophysis using immunohistochemistry and nicotinamide adenine dinucleotide phosphate diaphorase histochemistry. A population of NOS-positive cells was localized in very close contact with the sinusoidal capillaries. The pattern of this perivascular localization was either unicellular, bicellular or multicellular. These observations suggest that, at least, some actions of NO in the adenohypophysis can be accounted for by a local regulation of the glandular microvasculature.