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Related Experiment Videos

Age-related decrease in centrally-mediated pressor response to clonidine in conscious rats

H Kawasaki1, H Araki, K Futagami

  • 1Department of Clinical Pharmaceutical Science, Faculty of Pharmaceutical Sciences, Okayama University, Japan. kawasaki@pheasant.pharm.okayama-u.ac.jp

Brain Research
|March 31, 1998
PubMed
Summary
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Aging diminishes the pressor response to intracerebroventricular clonidine in rats, revealing a dose-dependent depressor effect. Heart rate changes were unaffected by age, suggesting central mechanisms are age-related.

Area of Science:

  • Neuroscience
  • Pharmacology
  • Gerontology

Background:

  • Clonidine is an alpha-2 adrenergic agonist used to treat hypertension.
  • Central administration of clonidine can elicit complex cardiovascular responses.
  • Age-related changes in drug responses are common but not fully understood.

Purpose of the Study:

  • To investigate age-related changes in the pressor and depressor responses to intracerebroventricular clonidine in rats.
  • To determine if age affects the cardiovascular responses to central clonidine administration.

Main Methods:

  • Intracerebroventricular injections of clonidine (2-20 micrograms) were administered to conscious rats of different ages (15, 20, and 30 weeks).
  • Blood pressure and heart rate were continuously monitored.

Related Experiment Videos

  • Dose-dependent responses were analyzed across age groups.

    • Main Results:

    • In 15-week-old rats, clonidine induced a dose-dependent pressor response and heart rate decrease, with a depressor response at lower doses.
    • In 20- and 30-week-old rats, the pressor response to clonidine was significantly reduced, and a depressor response was observed at all tested doses.
    • No age-related differences in heart rate response to clonidine were observed.

    Conclusions:

    • The centrally mediated pressor response to clonidine is significantly attenuated with age in rats.
    • Aging unmasks a depressor response to central clonidine, suggesting a shift in the balance of central autonomic regulation.
    • These findings highlight age-dependent alterations in the central mechanisms governing cardiovascular responses to alpha-2 adrenergic agonists.