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The global problem of antimicrobial resistance
Journal of the American Pharmaceutical Association (Washington, D.C. : 1996)
|July 1, 1997
Summary
Multidrug-resistant Streptococcus pneumoniae and Mycobacterium tuberculosis pose significant threats. Combating antimicrobial resistance requires surveillance and multidisciplinary strategies to address drug inactivation, altered permeability, and target site changes.
Area of Science:
- Microbiology
- Infectious Diseases
- Public Health
Background:
- Increasing prevalence of multidrug-resistant pathogens like Streptococcus pneumoniae in healthcare settings.
- The global AIDS pandemic exacerbates the threat of antimicrobial resistance in Mycobacterium tuberculosis.
Purpose of the Study:
- To highlight the growing concern of antimicrobial resistance.
- To outline the molecular mechanisms underlying antimicrobial resistance.
- To emphasize the importance of surveillance and multidisciplinary approaches in combating resistance.
Main Methods:
- Review of existing literature on antimicrobial resistance.
- Identification of key resistant pathogens and contributing factors.
- Analysis of molecular mechanisms of resistance.
Main Results:
- Streptococcus pneumoniae identified as a significant multidrug-resistant pathogen.
- Mycobacterium tuberculosis resistance amplified by the AIDS pandemic.
- Three primary molecular mechanisms of antimicrobial resistance identified: drug inactivation, altered cell permeability, and target site alteration.
Conclusions:
- Antimicrobial resistance is a serious global health threat requiring urgent attention.
- Effective containment necessitates robust surveillance systems and collaborative, multidisciplinary strategies.
- Understanding the molecular basis of resistance is crucial for developing effective interventions.