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Related Experiment Videos

Pituitary adenomas in the old-aged

C Z Chang1, C J Wang, S L Hwang

  • 1Department of Surgery, Kaohsiung Medical College Hospital, Taiwan, Republic of China.

The Kaohsiung Journal of Medical Sciences
|March 31, 1998
PubMed
Summary

Older patients with pituitary adenomas often experience neurological deficits like headaches and vision loss. Transsphenoidal surgery is a safe option for this demographic, with tumors being more frequently endocrine-inactive.

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Area of Science:

  • Neuroscience
  • Endocrinology
  • Oncology

Background:

  • Pituitary adenomas are common tumors affecting the endocrine system.
  • Understanding age-related differences in pituitary adenoma presentation and characteristics is crucial for effective treatment.

Purpose of the Study:

  • To investigate the clinical, pathological, and hormonal characteristics of pituitary adenomas in elderly patients (over 60).
  • To compare these features with those typically observed in younger patients.
  • To evaluate the safety and efficacy of transsphenoidal surgery in older individuals.

Main Methods:

  • Retrospective study of 29 patients over 60 years old diagnosed with pituitary adenoma between 1986 and 1996.
  • Analysis of clinical symptoms, pathological findings, immunoperoxidase staining, electron microscopy, and hormone levels.

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  • Comparison with data from younger patients.

    • Main Results:

    • Elderly patients more frequently presented with neurological deficits (headache, visual problems) compared to endocrine disturbances.
    • Tumor cells in older patients showed fewer subcellular organelles and secretary granules, though granules were larger in functioning tumors (e.g., prolactinomas).
    • Plurihormonal and endocrine-inactive pituitary adenomas were more common in the elderly group.

    Conclusions:

    • Transsphenoidal surgery is a feasible and safe surgical approach for pituitary adenomas in elderly patients.
    • Pituitary adenomas in the aged population are more prone to causing neurological deficits than endocrine imbalances.
    • The higher incidence of endocrine-inactive tumors in older individuals warrants specific diagnostic and management considerations.