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Effect of repeated oral infection of hamsters with scrapie
H Diringer1, J Roehmel, M Beekes
1Robert Koch-Institut, Bundesinstitut für Infektionskrankheiten und nicht übertragbare Krankheiten, Berlin, Germany.
The Journal of General Virology
|March 31, 1998
Abstract:
The development of a transmissible spongiform encephalopathy upon uptake of the infectious agent in feed was studied in the model system scrapie in hamsters. Compared to single dosing, repeated dosing caused disease at a considerable higher incidence. The risk of infection was higher when the time interval between repetitive dosing was short. There was a statistically significant trend of clearance of infectivity with time.
