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Related Experiment Videos

Dermatomyositis: a dermatology-based case series

M A Dawkins1, J L Jorizzo, F O Walker

  • 1Department of Dermatology, Bowman Gray School of Medicine of Wake Forest University, Winston-Salem, North Carolina 27157-1071, USA.

Journal of the American Academy of Dermatology
|March 31, 1998
PubMed
Summary
This summary is machine-generated.

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High-dose prednisone treatment effectively resolved myositis in 85% of dermatomyositis patients. This study reviewed clinical features and treatment responses, finding less active myositis at presentation compared to previous reports.

Area of Science:

  • Rheumatology
  • Immunology
  • Dermatology

Background:

  • Dermatomyositis presents significant morbidity and mortality risks.
  • Lack of established treatment consensus for dermatomyositis poses clinical challenges.

Purpose of the Study:

  • To review dermatomyositis clinical features and treatment responses.
  • To compare findings with prior dermatomyositis/polymyositis patient series.

Main Methods:

  • Retrospective review of 65 dermatomyositis patients over 10 years.
  • Prospective, uncontrolled study of 21 patients treated with high-dose prednisone and slow tapering.

Main Results:

  • Clinical features were consistent with prior descriptions, but patients presented with greater muscle strength.

Related Experiment Videos

  • Malignancy occurred in 12% of adult patients; dermatomyositis sine myositis was noted in 12 patients.
  • 85% of patients receiving prednisone showed myositis resolution.

    • Conclusions:

    • Dermatomyositis patients in this cohort had less active myositis at presentation.
    • High-dose daily prednisone with slow tapering proved effective for treating dermatomyositis.