Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Serologic testing of cornea donors

D B Glasser1

  • 1Patuxent Medical Group, Columbia, Maryland 21045, USA.

Cornea
|March 31, 1998
PubMed
Summary
This summary is machine-generated.

Cornea donor screening, including serologic testing for infectious diseases, ensures transplant safety. Current Eye Bank Association of America (EBAA) requirements have maintained an excellent safety record for corneal transplantation.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Tolterodine extended release is well tolerated in older subjects.

International journal of clinical practice·2009
Same author

A population-based survey of sexual activity, sexual problems and associated help-seeking behavior patterns in mature adults in the United States of America.

International journal of impotence research·2009
Same author

Relationships between improvements in symptoms and patient assessments of bladder condition, symptom bother and health-related quality of life in patients with overactive bladder treated with tolterodine.

International journal of clinical practice·2008
Same author

Cardiovascular outcomes among sildenafil users: results of the International Men's Health Study.

International journal of clinical practice·2008
Same author

Prevalence of storage and voiding symptoms among men aged 40 years and older in a US population-based study: results from the Male Attitudes Regarding Sexual Health study.

International journal of clinical practice·2007
Same author

A retrospective study of the relationship between biomarkers of atherosclerosis and erectile dysfunction in 988 men.

International journal of impotence research·2006
Same journal

Corneal Tissue Addition Keratoplasty.

Cornea·2026
Same journal

Corneal Tissue Addition Keratoplasty for Keratoconus: Point-Counterpoint.

Cornea·2026
Same journal

Posterior Segment Pressurization With Intravitreal Balanced Salt Solution to Stabilize Anterior Chamber Gas During Endothelial Keratoplasty.

Cornea·2026
Same journal

Central Corneal Thickness Six Postoperative Months After DMEK or Triple-DMEK.

Cornea·2026
Same journal

Rebubbling and Graft Detachment in Pre-Descemet Endothelial Keratoplasty: A Prospective Study.

Cornea·2026
Same journal

Letter Regarding: ESCALÓN: A Prospective Randomized Trial of Corneal Endothelial Cell Therapy in Subjects With Corneal Edema.

Cornea·2026
See all related articles

Area of Science:

  • Ophthalmology
  • Transplantation Immunology
  • Infectious Disease Control

Background:

  • Corneal transplantation carries a theoretical risk of infectious disease transmission.
  • Serologic testing of cornea donors is crucial for mitigating this risk.
  • Regulations from the Eye Bank Association of America (EBAA) and Food and Drug Administration (FDA) guide donor screening.

Purpose of the Study:

  • To review current serologic testing requirements for cornea donors.
  • To examine the rationale behind these testing protocols.
  • To provide guidelines for managing results of non-required tests.

Main Methods:

  • Examination of EBAA and FDA regulations.
  • Review of current knowledge on infectious disease transmission via corneal grafts.

Related Experiment Videos

  • Analysis of safety data related to corneal transplantation.

    • Main Results:

    • Mandatory screening for human immunodeficiency virus (HIV) 1 and 2, hepatitis B surface antigen (HBsAg), and hepatitis C virus (HCV).
    • Commonly performed additional tests include hepatitis B core antibody (anti-HBc), syphilis, cytomegalovirus (CMV), and human T-lymphotropic virus (HTLV) I and II.
    • Over 400,000 corneas transplanted in 12 years with no reported systemic infectious disease transmission from EBAA-member banks.

    Conclusions:

    • EBAA donor-screening requirements, including serologic testing, have established an excellent safety record.
    • Ongoing review of serologic testing requirements is necessary as new scientific information emerges.