Peters' anomaly associated with protruding corneal pseudo staphyloma
Related Experiment Video
Updated: Oct 30, 2026

Iris Fixation via External Pentagram Suturing
Published on: May 5, 2022
1Westchester Medical Center, Our Lady of Mercy Hospital, New York Medical College, Department of Ophthalmology, Valhalla 10595, USA.
Insights
This study describes a novel Peters
Area of Science:
- Ophthalmology
- Genetics
- Pediatric Medicine
Background:
- Peters' anomaly is a rare congenital corneal defect.
- It is characterized by a central corneal opacity and iridocorneal adhesions.
- This condition can lead to severe vision impairment.
Observation:
- Four infants presented with a unique Peters' anomaly manifestation.
- Affected eyes showed thickened, scarred corneas resembling congenital anterior staphyloma.
- Ocular findings varied from normal to severe anomalies in the contralateral eye.
Findings:
- Corneal transplants were performed on affected eyes.
- Three out of four corneal grafts maintained clarity for over a year.
- Vision was restored in three eyes; two developed glaucoma.
- Histopathology confirmed Peters' anomaly in corneal buttons.
Implications:
- This presentation expands the spectrum of Peters' anomaly.
- Surgical intervention (corneal transplant) improved cosmetic appearance and vision.
- Early diagnosis and management are crucial for visual outcomes in Peters' anomaly.
Purpose:
To describe a new manifestation of Peters' anomaly.
Methods:
We managed four infants with an unusual form of Peters' anomaly. One eye of each patient had a thickened and scarred cornea, mimicking a corneal staphyloma, protruding anteriorly from the corneal plane. The other eye of each patient ranged from normal to having severe ocular anomalies. A corneal transplant was performed in each case.
Results:
Follow-up ranged from 1 to 3 years. Three eyes maintained graft clarity for at least 1 year. Each of these eyes developed vision. Two of these eyes developed glaucoma. The one eye with graft failure developed an inoperable retinal detachment. The histopathology of each corneal button showed changes consistent with Peters' anomaly.
Conclusions:
These corneas demonstrated characteristics of both Peters' anomaly and congenital anterior staphyloma. Despite their severe anomalies, surgery successfully restored a more normal cosmetic appearance in all four eyes and vision in three eyes.
Related Concept Videos
Staphylococcal Skin Infections
Glaucoma: Overview
