Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Native pulmonary muscular proliferation

W Wöckel1, P Meister, O Karg

  • 1Pathologisches Institut, Zentralkrankenhauses Gauting der LVA Oberbayern, Germany.

Pathology, Research and Practice
|January 1, 1997
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Smaller panel, similar results: genomic profiling and molecularly informed therapy in pancreatic cancer.

ESMO open·2023
Same author

Airway-centered interstitial fibrosis - an under-recognized subtype of diffuse parenchymal lung diseases.

Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG·2020
Same author

[Working Conditions and Quality of Specialized Training in Respiratory Medicine in Germany - Status quo, Challenges and Perspectives].

Pneumologie (Stuttgart, Germany)·2019
Same author

[Symptomatic abdominal wall tumor : Nausea, vomiting and abdominal cramp due to a lipomatous lesion of the left abdominal wall].

Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen·2019
Same author

[Vascularized tumor of the retroauricular skin].

Der Pathologe·2018
Same author

[How to become a Respiratory Therapist in Germany - Status quo and Development Prospects].

Pneumologie (Stuttgart, Germany)·2017
Same journal

Autophagy modulation in ulcerative colitis with traditional Chinese medicine: A review.

Pathology, research and practice·2026
Same journal

Ras signalling in infectious disease pathology: Mechanisms, tissue damage, and clinical implications.

Pathology, research and practice·2026
Same journal

CBFβ-SMMHC in inv(16) AML: Fusion biology, RUNX1 dysregulation, and therapeutic targeting of a leukemogenic protein-protein interaction.

Pathology, research and practice·2026
Same journal

Multifactorial pathophysiology of varicocele: Integrating hemodynamic, oxidative, and endocrine mechanisms.

Pathology, research and practice·2026
Same journal

Comparative pathophysiology and pathology of transient ischemic attack, ischemic stroke, and reperfusion injury: Mechanistic and therapeutic perspectives.

Pathology, research and practice·2026
Same journal

Taraxerol targets the HIF1A-NEK6 axis to block TDE-mediated M2 macrophage polarization and inhibits NSCLC progression.

Pathology, research and practice·2026
See all related articles

Native pulmonary muscular proliferation (NPMP) is a rare lung condition that can be mistaken for pulmonary lymphangioleiomyomatosis (PLAM). Immunohistochemistry is crucial for distinguishing NPMP from PLAM, especially in small biopsies.

Area of Science:

  • Pulmonary Pathology
  • Histopathology
  • Differential Diagnosis

Background:

  • Native pulmonary muscular proliferation (NPMP) is a rare lung condition with an unknown etiology.
  • NPMP can be clinically and histologically misdiagnosed as pulmonary lymphangioleiomyomatosis (PLAM) in transbronchial biopsies.

Observation:

  • Distinguishing NPMP from PLAM is critical due to PLAM's poor prognosis and association with tuberous sclerosis.
  • Histological differences, such as desmin staining patterns and cell distribution, may be subtle in small biopsies.
  • Immunohistochemical markers, including HMB45, estrogen, and progesterone receptors, aid in differentiating NPMP from PLAM.

Findings:

  • NPMP exhibits a distinct pattern of mature and immature muscle cell proliferation, often with a fascicular arrangement.

Related Experiment Videos

  • PLAM typically shows positive staining for estrogen and progesterone receptors and consistently positive HMB45 in muscle cells.
  • NPMP muscle cells are negative for HMB45.

    • Implications:

    • Accurate diagnosis of NPMP is important as it is a clinically benign condition.
    • Immunohistochemistry is essential for reliable differentiation of NPMP from PLAM in small tissue samples.
    • This distinction prevents misdiagnosis and unnecessary aggressive treatment for patients with NPMP.