Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Factors determining the therapeutic window for stroke

¹Department of Neurosciences, University of California San Diego, La Jolla 92093-0624, USA.

|April 1, 1998

Summary

The therapeutic window for acute cerebral ischemia is critical for stroke treatment. Animal studies show irreversible injury begins within minutes and completes within 6 hours, emphasizing the need for urgent patient care.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

NeuroThera® Efficacy and Safety Trial-3 (NEST-3): a double-blind, randomized, sham-controlled, parallel group, multicenter, pivotal study to assess the safety and efficacy of transcranial laser therapy with the NeuroThera® Laser System for the treatment of acute ischemic stroke within 24 h of stroke onset.

International journal of stroke : official journal of the International Stroke Society·2012

Same author

The STRokE DOC trial technique: 'video clip, drip, and/or ship'.

International journal of stroke : official journal of the International Stroke Society·2008

Same author

Hemorrhagic stroke in the Stroke Prevention by Aggressive Reduction in Cholesterol Levels study.

Neurology·2007

Same author

Baicalein, an antioxidant 12/15-lipoxygenase inhibitor improves clinical rating scores following multiple infarct embolic strokes.

Neuroscience·2007

Same author

Editorial commentary.

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association·2007

Same author

Combination treatment for acute ischemic stroke: A ray of Hope?

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association·2007

Area of Science:

Neurology
Pharmacology
Medical Research

Background:

The advent of effective stroke medications necessitates understanding treatment time windows.
Acute cerebral ischemia poses a significant challenge in clinical neurology.

Purpose of the Study:

To analyze the time frame for treating acute cerebral ischemia.
To evaluate the duration of irreversible injury in stroke.

Main Methods:

Statistical analysis of animal studies on cerebral ischemia.
Review of clinical trial data for empirical therapeutic window estimation.

Main Results:

Irreversible focal injury in animal models begins within minutes and is complete by approximately 6 hours.
Accurate estimation of ischemic duration in patients faces technical challenges.

Conclusions:

Urgent treatment is essential for optimal stroke care.
Further research is needed to overcome technical obstacles in estimating ischemic duration in patients.

Related Experiment Videos