Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Paraneoplastic necrotizing myopathy: clinical and pathological features

M I Levin1, T Mozaffar, M T Al-Lozi

  • 1Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA.

Neurology
|April 1, 1998
PubMed
Summary

Paraneoplastic necrotizing myopathy presents as rapid, severe muscle weakness. Early cancer evaluation is crucial for diagnosis and treatment of this rare condition.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

2024 VCP International Conference: Exploring multi-disciplinary approaches from basic science of valosin containing protein, an AAA+ ATPase protein, to the therapeutic advancement for VCP-associated multisystem proteinopathy.

Neurobiology of disease·2025
Same author

Genotype-phenotype study in patients with valosin-containing protein mutations associated with multisystem proteinopathy.

Clinical genetics·2017
Same author

Seropositivity for NT5c1A antibody in sporadic inclusion body myositis predicts more severe motor, bulbar and respiratory involvement.

Journal of neurology, neurosurgery, and psychiatry·2015
Same author

Activation of the Wnt/β-catenin signaling cascade after traumatic nerve injury.

Neuroscience·2015
Same author

Genotype-phenotype studies of VCP-associated inclusion body myopathy with Paget disease of bone and/or frontotemporal dementia.

Clinical genetics·2012
Same author

Slow development of ALS-like spinal cord pathology in mutant valosin-containing protein gene knock-in mice.

Cell death & disease·2012

Area of Science:

  • Neurology
  • Oncology
  • Pathology

Background:

  • Paraneoplastic syndromes are common neurological complications of cancer.
  • Necrotizing myopathy is a rare manifestation, with limited case reports available.
  • This study aims to detail the clinical and pathological characteristics of paraneoplastic necrotizing myopathy.

Observation:

  • Four patients with paraneoplastic necrotizing myopathy were identified over a 10-year period.
  • Patients presented with subacute, symmetric, proximal muscle weakness.
  • Associated cancers included gastrointestinal adenocarcinoma, transitional cell carcinoma, prostatic carcinoma, and non-small cell lung carcinoma.

Findings:

  • Muscle biopsies revealed significant fiber necrosis (8-100%) and intense alkaline phosphatase staining in connective tissue.

Related Experiment Videos

  • Little to no inflammation was observed in muscle tissue.
  • Two patients experienced improvement with corticosteroids and tumor resection, while two passed away.

    • Implications:

    • Paraneoplastic necrotizing myopathy is a severe condition causing rapid, disabling weakness.
    • Distinctive muscle pathology aids in diagnosis.
    • Prompt cancer screening is essential for patients presenting with these clinical and pathological features.