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Related Experiment Videos

Factors associated with atypical nevi: a population-based study

L Titus-Ernstoff1, E Mänsson-Brahme, M Thorn

  • 1Department of Community and Family Medicine, Dartmouth Medical School, Hanover, New Hampshire, USA.

Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology
|April 1, 1998
PubMed
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The number of benign nevi significantly predicts atypical nevi risk. High benign nevus counts (≥100) increase atypical nevus likelihood 26-fold, highlighting nevus count as a key factor.

Area of Science:

  • Dermatology
  • Epidemiology
  • Genetics

Background:

  • Clinically atypical nevi are a risk factor for melanoma.
  • Understanding risk factors for atypical nevi is crucial for early detection and prevention strategies.

Purpose of the Study:

  • To identify factors associated with the presence of clinically atypical nevi in a population-based cohort of Swedish women.
  • To investigate the relationship between benign nevus count, sun exposure, tanning ability, and other risk factors with the development of atypical nevi.

Main Methods:

  • A case-control study was conducted using a two-staged sampling scheme from a cohort of 50,000 Swedish women.
  • Participants underwent physician-conducted skin examinations to identify cases (at least one atypical nevus) and controls (no atypical nevi), and to count benign nevi.

Related Experiment Videos

  • Risk factor information, including sun exposure history and tanning habits, was collected via a health survey questionnaire.

    • Main Results:

    • A strong, statistically significant relationship was found between the number of benign nevi and the presence of atypical nevi (P < 0.0001).
    • Women with 100 or more benign nevi had a 26-fold increased likelihood of having an atypical nevus.
    • Interactions were observed: in women with low benign nevus counts (<50), freckling and early sun exposure were associated with atypical nevi; in women with high counts (≥50), difficulty tanning and lack of sunburns (ages 10-19) increased risk, with a suggested inverse relationship with parity.

    Conclusions:

    • The number of benign nevi is a powerful predictor of clinically atypical nevi.
    • Risk factor associations with atypical nevi differ based on the number of benign nevi, suggesting distinct etiological pathways.
    • These findings emphasize the importance of nevus counting in dermatological assessments and risk stratification for melanoma.