Transforming growth factor-beta gene expression in avian Low Score Normal pectoral muscle
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Updated: Oct 30, 2026

In Ovo Feeding of Commercial Broiler Eggs: An Accurate and Reproducible Method to Affect Muscle Development and Growth
Published on: September 20, 2021
1Department of Animal Sciences, Ohio Agricultural Research and Development Center, The Ohio State University, Wooster 44691, USA. velleman.1@osu.edu
Abstract:
The avian Low Score Normal (LSN) genetic muscle weakness is phenotypically characterized by a reduction in the ability of birds to right themselves from a supine position. In previous studies, LSN birds exhibited elevated levels of decorin transcript and protein at embryonic Day 20 and a large increase in collagen crosslinking at 6 wk posthatch. Transforming growth factor-beta (TGF-beta) expression has been reported to control decorin expression. Steady state levels of TGF-beta1 and TGF-beta2 transcripts were determined in ovo and posthatch in order to initiate an investigation of the mechanism underlying decorin expression. On embryonic Day 20 through 1 wk posthatch, TGF-beta2 transcript levels were elevated, whereas an increase in TGF-beta1 was only noted at 1 d posthatch. These data suggest that the increase in decorin expression may be associated with a modification in a TGF-beta signal transduction pathway.
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