Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Further support for nitric oxide-dependent memory processing in the day-old chick

N S Rickard1, K T Ng, M E Gibbs

  • 1Department of Psychology, Monash University, Clayton, Victoria, 3168, Australia. n.rickard@sci.monash.edu.au

Neurobiology of Learning and Memory
|June 20, 1998
PubMed
Summary

Nitric oxide (NO) activity is crucial for memory consolidation. Inhibiting NO synthase shortly after training impaired memory in chicks, demonstrating NO

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Prophylactic intravenous tranexamic acid and thromboembolism in non-cardiac surgery: a systematic review, meta-analysis and trial sequential analysis.

Anaesthesia·2023
Same author

Author Reply.

Prehospital and disaster medicine·2020
Same author

The Effect of Prehospital Epinephrine in Out-of-Hospital Cardiac Arrest: A Systematic Review and Meta-Analysis.

Prehospital and disaster medicine·2019
Same author

The effect of dexmedetomidine on delirium and agitation in patients in intensive care: systematic review and meta-analysis with trial sequential analysis.

Anaesthesia·2018
Same author

Peri-implant inflammation and marginal bone level changes around dental implants in relation to proximity with and bone level of adjacent teeth.

Australian dental journal·2018
Same author

Continuous infusion vs. intermittent bolus injection of furosemide in acute decompensated heart failure: systematic review and meta-analysis of randomised controlled trials.

Anaesthesia·2017

Area of Science:

  • Neuroscience
  • Memory Research
  • Biochemistry

Background:

  • Nitric oxide (NO) is increasingly recognized for its role in memory formation.
  • Previous studies using NO synthase inhibitors suggest NO's involvement in memory.
  • The specific stage of memory processing influenced by NO remains unclear.

Purpose of the Study:

  • To systematically investigate the role of nitric oxide activity in different stages of memory formation.
  • To determine if NO is required during or after the learning process for memory consolidation.

Main Methods:

  • Day-old chicks were trained on a passive avoidance task.
  • Intracranial injections of nitric oxide synthase inhibitors (l-NG-nitroarginine methylester and l-NG-nitroarginine) were administered pre- or post-training.

Related Experiment Videos

  • The effect of NO donors (sodium nitroprusside) was also examined.

    • Main Results:

    • Inhibition of nitric oxide synthase shortly after training significantly impaired memory formation.
    • This memory impairment was observed regardless of whether the inhibitor was given pre- or post-training.
    • Administration of a nitric oxide donor counteracted the inhibitory effects.

    Conclusions:

    • Nitric oxide activity is critical for the consolidation phase of memory.
    • These findings highlight NO's essential role in stabilizing newly formed memories.
    • The study provides strong evidence for NO's involvement in the molecular mechanisms of memory.