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Published on: July 10, 2012
Acute otitis media in children with bronchiolitis
M A Andrade1, A Hoberman, J Glustein
1Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Insights
Bacterial acute otitis media (AOM) frequently complicates bronchiolitis in children. This study found bacterial pathogens in most AOM cases, indicating antimicrobial treatment is necessary for these young patients.
Area of Science:
- Pediatrics
- Infectious Diseases
- Otolaryngology
Background:
- Bronchiolitis is a common respiratory infection in infants.
- Acute otitis media (AOM) often co-occurs with bronchiolitis.
- The role of respiratory syncytial virus (RSV) versus bacteria in AOM during bronchiolitis is debated.
Purpose of the Study:
- To determine the prevalence and causes of AOM in children with bronchiolitis.
- To assess if AOM in this population is primarily viral (RSV) or bacterial.
- To inform appropriate treatment strategies for AOM in bronchiolitis patients.
Main Methods:
- Study included 42 children aged 2-24 months with bronchiolitis.
- Middle-ear aspirates analyzed for bacteria (Gram stain, culture) and RSV (RT-PCR).
- Patients with AOM monitored for development of other otitis media types.
Main Results:
- 62% of children with bronchiolitis developed AOM.
- Bacterial pathogens were identified in all AOM cases.
- Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis were common isolates.
- RSV was detected in 71% of AOM patients, but bacteria were consistently present.
Conclusions:
- Bacterial AOM is a frequent complication of bronchiolitis.
- Antimicrobial treatment is indicated for children with bronchiolitis and AOM.
- RSV presence does not preclude bacterial etiology in AOM during bronchiolitis.
Objective:
We investigated the prevalence and the etiology of acute otitis media (AOM) in children with bronchiolitis to determine whether AOM in such children is due entirely or mainly to respiratory syncytial virus (RSV), in which case routine antimicrobial treatment would not be appropriate.
Methods:
The study group consisted of children aged 2 to 24 months with bronchiolitis. In patients with AOM at entry, nasal washings for RSV enzyme-linked immunosorbent assay were obtained, and Gram-stained smear, bacterial culture, and reverse transcriptase polymerase chain reaction to detect the presence of RSV were performed on middle-ear aspirates. Patients without AOM were reevaluated at 48 to 72 hours, 8 to 10 days, and 18 to 22 days.
Results:
Forty-two children with bronchiolitis were enrolled. Sixty-two percent had AOM at entry or developed AOM within 10 days. An additional 24% had or eventually developed otitis media with effusion. Only 14% remained free of both AOM and otitis media with effusion throughout the 3-week observation period. All patients with AOM had 1 or more bacterial pathogens isolated from one or both middle-ear aspirates. Of 33 middle-ear aspirates, Streptococcus pneumoniae was isolated in 15, Haemophilus influenzae in 8, Moraxella catarrhalis in 8, and Staphylococcus aureus in 2. Two middle-ear aspirates yielded 2 pathogens each; 2 aspirates had no growth. RSV was identified in 17 (71%) of 24 patients with AOM.
Conclusion:
Bacterial AOM is a complication in most children with bronchiolitis. Accordingly, in patients with bronchiolitis and associated AOM, antimicrobial treatment is indicated.
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