Electrochemical determination of ibuprofen

Two simple and accurate electrochemical methods for the determination of ibuprofen (CAS 15687-27-1) as a bulk drug and as an active compound in pharmaceutical formulations are presented. For the potentiometric determination of ibuprofen sodium hydroxide and triethanolamine were used as titrants. The influence of different solvents, such as water, methanol, acetonitrile, dimethyl sulfoxide and N,N-dimethylformamide, on the conductometric titrations was investigated. The same titrants as in the potentiometric titrations were used. The methods are accurate and results are reproducible in quantities ranging from 1 to 10 mg of ibuprofen in analysed pharmaceutical dosage forms. The relative standard deviation (n = 10) varies over the range 0.38-1.63%.