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Inhibition of lipid peroxidation
1Chemistry Department, Huazhong University of Science and Technology Wuhan, People's Republic of China.
Abstract:
Lipid peroxy radicals (ROO.) were detected by electron spin resonance (ESR) at low temperature after formation by addition of H2O2 into a suspension of mice lymphocytes. If lymphocytes were treated with selenomethionine (Se-Met) prior to addition of H2O2, ROO. formation was inhibited in a fashion that was dependent on Se-Met concentration. Formation of ROO. in the spleen of mice was induced by 60Co irradiation. Animals that were supplemented with Na2SeO3 prior to irradiation exhibited a lower ROO. concentration than that of nontreated animals. Based on our experiments, we have concluded that Se has an oxygen-free radical scavenging effect. This should be a protective effect against lipid peroxy radical cellular attack.