Local luminance and pattern reversal stimuli yield different visual evoked potential topography

We studied how the stimulation of quadrants of the visual field affect brain potential topography, and we compared activity elicited by conventional pattern reversal or by local luminance stimuli. The method of quasi-simultaneous stimulation of many small visual field elements by binary m-sequences allowed us to reconstruct the potentials evoked at each of 54 visual field locations independently. Data from all field elements within each quadrant and in the whole stimulation field were summed and compared to those elicited by checkerboard reversal stimuli presented in the four quadrants or as full field stimuli. In twenty-two healthy adults evoked brain activity was recorded in 30 channels with an electrode array densely spaced over the occipital brain areas. With local flash stimuli as well as with checkerboard reversal the topographical distributions of cortical activation changed significantly with retinal stimulus location. Analysis of three components occurring between 50 and 240 ms revealed significant differences between pattern reversal and local luminance evoked brain activity. Reversal stimuli yielded not only larger amplitudes but also a completely different component structure and topography. Our results illustrate that different neuronal generators are activated by pattern reversal and local luminance stimuli although visual field location of the stimuli was identical indicating that the same retinal and cortical structures respond in a different way depending on stimulation mode.