Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Adrenalectomy-induced neuronal degeneration

K M MacLennan1, P F Smith, C L Darlington

  • 1Department of Pharmacology, School of Medical Sciences, University of Otago Medical School, Dunedin, New Zealand.

Progress in Neurobiology
|April 2, 1998
PubMed
Summary

Adrenalectomy, the removal of adrenal glands, triggers cell death in the hippocampus. This review focuses on understanding this glucocorticoid-mediated effect in the central nervous system (CNS).

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

New software dedicated to virtual mazes for human cognitive investigations.

Journal of neuroscience methods·2019
Same author

The critical role of vestibular graviception during cognitive-motor development.

Behavioural brain research·2019
Same author

Hippocampal LTP modulation and glutamatergic receptors following vestibular loss.

Brain structure & function·2018
Same author

Flow cytometry for receptor analysis from ex-vivo brain tissue in adult rat.

Journal of neuroscience methods·2018
Same author

Cost-utility analysis of antiviral use under pandemic influenza using a novel approach - linking pharmacology, epidemiology and heath economics.

Epidemiology and infection·2018
Same author

Further studies of the effects of aging on arginine metabolites in the rat vestibular nucleus and cerebellum.

Neuroscience·2017

Area of Science:

  • Neuroscience
  • Endocrinology
  • Cell Biology

Background:

  • Glucocorticoids bind to central nervous system (CNS) receptors, modulating vital processes like neurotransmission and cell survival.
  • Adrenalectomy, the surgical removal of adrenal glands, disrupts physiological functions across the brain due to the absence of glucocorticoids.

Purpose of the Study:

  • To review research on glucocorticoid-mediated CNS effects.
  • To specifically focus on the phenomenon of adrenalectomy-induced hippocampal cell death.

Main Methods:

  • Literature review of existing research on glucocorticoid effects in the CNS.
  • Focus on studies investigating hippocampal cell death following adrenalectomy.

Main Results:

Related Experiment Videos

  • Glucocorticoid withdrawal after adrenalectomy leads to disruptions in various brain functions.
  • A significant finding is the induction of cell death within the hippocampus post-adrenalectomy.

    • Conclusions:

    • Glucocorticoids play a critical role in maintaining hippocampal cell survival.
    • Adrenalectomy-induced hippocampal cell death is a significant area requiring further investigation within neuroendocrinology.