Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Can antioxidant supplementation slow the aging process?

B P Yu1, C M Kang, J S Han

  • 1Department of Physiology, University of Texas Health Science Center, San Antonio 78284-7756, USA.

Biofactors (Oxford, England)
|April 2, 1998
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The effects of urban green space and road proximity to indoor traffic-related PM<sub>2.5</sub>, NO<sub>2</sub>, and BC exposure in inner-city schools.

Journal of exposure science & environmental epidemiology·2024
Same author

Radiation shielding analysis of a special linear accelerator for electron beam and X-ray.

Journal of X-ray science and technology·2017
Same author

Tissue-specific susceptibility to peroxyl radical-mediated inhibition of mitochondrial transcription.

Redox report : communications in free radical research·2016
Same author

Optimal assessment of lymph node status in gallbladder cancer.

European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·2015
Same author

Prevalence and clinical significance of cellular and acellular mucin in patients with locally advanced mucinous rectal cancer who underwent preoperative chemoradiotherapy followed by radical surgery.

Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland·2015
Same author

Serous cystic neoplasm of the pancreas: a multinational study of 2622 patients under the auspices of the International Association of Pancreatology and European Pancreatic Club (European Study Group on Cystic Tumors of the Pancreas).

Gut·2015
Same journal

Alpinia zerumbet-Derived Extracellular Vesicles Protect Against UVB-Induced Photoaging by Enhancing Mitochondrial Bioenergetics and Skin Barrier Function.

BioFactors (Oxford, England)·2026
Same journal

Integrative Multi-Omics Analysis Reveals the Tumor-Suppressive and Immunoregulatory Roles of SEMA5B in Prostate Cancer.

BioFactors (Oxford, England)·2026
Same journal

Dauriporphine Inhibits the Proliferation, Migration, Angiogenesis, and Glycolysis in Lung Cancer Cells by Repressing PGK1 Expression via CEBPA.

BioFactors (Oxford, England)·2026
Same journal

An AI-Driven Multi-Omics Framework Identifies CASP8 as a Clinically Actionable Pyroptosis Biomarker in Bladder Cancer.

BioFactors (Oxford, England)·2026
Same journal

Targeting the Tumor Immune Ecosystem in Glioblastoma: Challenges and Innovations in Immunotherapy.

BioFactors (Oxford, England)·2026
Same journal

Platelet-Related Gene Signature Predicts Prognosis, Immune Landscape, and Drug Sensitivity in Acute Myeloid Leukemia.

BioFactors (Oxford, England)·2026
See all related articles

Antioxidant supplementation, like vitamin E, shows promise in extending lifespan and protecting against oxidative stress. However, long-term effects and optimal usage require further research into free radical metabolism.

Area of Science:

  • Gerontology
  • Biochemistry
  • Cell Biology

Background:

  • The oxidative stress theory of aging is supported by evidence from aging intervention studies.
  • Early studies demonstrated life span extension in experimental organisms through antioxidant supplementation.
  • Accumulating data highlight the role of antioxidants beyond free radical scavenging.

Purpose of the Study:

  • To review the anti-aging effects of dietary antioxidant supplementation.
  • To discuss potential challenges associated with long-term antioxidant administration.
  • To explore emerging physiological roles of antioxidants.

Main Methods:

  • Review of existing literature on antioxidant supplementation and aging.
  • Analysis of data from experimental organisms and human cell studies.

Related Experiment Videos

  • Examination of in vitro and in vivo studies on vitamin E and LDL oxidation.

    • Main Results:

    • Antioxidant feeding, such as 2-mercaptoethanol, prolonged median and maximum mouse lifespans.
    • Dietary vitamin E demonstrated protection against DNA oxidative damage in human lymphocytes.
    • Vitamin E suppressed LDL oxidation and showed potential in improving glucose transport and insulin sensitivity.

    Conclusions:

    • Dietary antioxidants, particularly vitamin E, offer anti-aging benefits by combating oxidative stress.
    • Emerging roles of antioxidants in metabolic regulation and cell proliferation warrant further investigation.
    • Long-term antioxidant supplementation requires a deeper understanding of free radical metabolism and endogenous defense mechanisms to mitigate potential risks.