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Related Experiment Videos

Peptide excretion in celiac disease

W H Reichelt1, J Ek, M Stensrud

  • 1Department of Pediatric Research, University of Oslo, Rikshospitalet, Norway.

Journal of Pediatric Gastroenterology and Nutrition
|April 2, 1998
PubMed
Summary

Celiac disease patients show increased peptide excretion in their urine, a condition known as hyperpeptiduria. This suggests potential systemic effects from these bioactive peptides.

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Area of Science:

  • Gastroenterology
  • Clinical Nutrition
  • Biochemistry

Background:

  • Celiac disease involves damage to the small intestine mucosa.
  • This study investigates altered peptide and protein absorption in celiac patients.

Purpose of the Study:

  • To determine if peptide and protein uptake from the gut is elevated in celiac disease.
  • To investigate the presence and quantity of low-molecular-weight peptides in celiac patients.

Main Methods:

  • Urine samples were collected from children and adults with untreated celiac disease.
  • Reversed-phase chromatography was employed to measure peptide levels.

Main Results:

  • Significantly increased excretion of low-molecular-weight peptides was observed in celiac patients.

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  • Peptide excretion levels were compared to an age- and sex-matched control group.

    • Conclusions:

    • Celiac patients exhibit hyperpeptiduria (elevated urinary peptide levels).
    • Bioactive peptides in urine may contribute to systemic effects observed in untreated celiac disease.