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Lipoamino acid conjugates of methotrexate with antitumor activity

R Pignatello1, G Jansen, I Kathmann

  • 1The Department of Pharmaceutical and Biological Chemistry, The School of Pharmacy, University of London, UK.

Journal of Pharmaceutical Sciences
|April 2, 1998
PubMed

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Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...