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[The current and future outlook in immunosuppressive therapy for children]
1Clinica a II-a Pediatrie, Universitatea de Medicină şi Farmacie Gr. T. Popa, Iaşi.
The various cell proportions that form the immune system intervene in the activation of autoreactive cells and in the occurrence of the associated inflammatory process. Advances of the study of the mechanism involved in the autoimmunity, and the development of new immunosuppressive agents used for transplantations have deeply modified the therapeutic approaches. The classic treatment of autoimmune diseases has relied on corticosteroids and immunosuppressive drugs. Now, these new treatments are evaluated on animal models, then controlled in clinical trials. Cyclosporin A has been shown to be effective in several autoimmune diseases. Intravenous immunoglobulins, cytokines, and anticytokines, immunotoxins, monoclonal anti-leukocyte antibodies (CD4, CD25) and soon peptide vaccination constitute the new types of treatments.
The various cell proportions that form the immune system intervene in the activation of autoreactive cells and in the occurrence of the associated inflammatory process. Advances of the study of the mechanism involved in the autoimmunity, and the development of new immunosuppressive agents used for transplantations have deeply modified the therapeutic approaches. The classic treatment of autoimmune diseases has relied on corticosteroids and immunosuppressive drugs. Now, these new treatments are evaluated on animal models, then controlled in clinical trials. Cyclosporin A has been shown to be effective in several autoimmune diseases. Intravenous immunoglobulins, cytokines, and anticytokines, immunotoxins, monoclonal anti-leukocyte antibodies (CD4, CD25) and soon peptide vaccination constitute the new types of treatments.