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Related Experiment Videos

HGF/SF in angiogenesis

E M Rosen1, K Lamszus, J Laterra

  • 1Department of Radiation Oncology, Long Island Jewish Medical Center, New Hyde Park, NY 11040, USA.

Ciba Foundation Symposium
|January 1, 1997
PubMed
Summary
This summary is machine-generated.

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Hepatocyte growth factor (HGF/SF) promotes cancer cell invasion and blood vessel growth (angiogenesis). This cytokine, acting via its receptor c-met, is overexpressed in invasive cancers, suggesting it drives tumor progression.

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Oncology

Background:

  • Hepatocyte growth factor/scatter factor (HGF/SF) is a cytokine that regulates cell motility and invasion.
  • The c-met proto-oncogene product is the receptor for HGF/SF, mediating cellular responses.
  • HGF/SF is implicated in various biological processes, including development and wound healing.

Purpose of the Study:

  • To investigate the role of HGF/SF in angiogenesis and tumor progression.
  • To determine if HGF/SF directly affects vascular endothelial cells.
  • To assess the impact of HGF/SF overexpression on tumor growth in vivo.

Main Methods:

  • Studied the effects of HGF/SF on vascular endothelial cell migration, proliferation, invasion, and tube formation.
  • Quantified HGF/SF levels in human breast cancers and correlated them with vascular markers.

Related Experiment Videos

  • Transfected cancer cell lines (breast cancer, glioma) with HGF/SF cDNA and evaluated tumor growth and angiogenesis in animal models.

    • Main Results:

    • HGF/SF directly stimulates vascular endothelial cells, promoting angiogenesis through enhanced migration, proliferation, invasion, and tube formation.
    • HGF/SF is overexpressed in invasive human cancers, particularly breast cancer, and correlates with vascular endothelial cell markers.
    • HGF/SF-transfected cancer cells exhibited significantly enhanced tumor growth in vivo, partly due to increased tumor angiogenesis.

    Conclusions:

    • HGF/SF is a potent angiogenic factor that directly acts on endothelial cells.
    • Overexpression of HGF/SF is associated with invasive cancers and contributes to tumor progression.
    • HGF/SF functions as a tumor progression factor by enhancing both cancer cell invasiveness and tumor angiogenesis.