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Increased tolerance to vecuronium in a patient with testicular feminization
1Department of Anesthesiology, College of Physicians & Surgeons of Columbia University, New York, NY, USA.
Journal of Clinical Anesthesia
|April 3, 1998
Abstract:
Muscle relaxant pharmacophysiology can be altered in various clinical situations. We report increased requirement of vecuronium in a patient diagnosed with testicular feminization. Increased level of endogenous testosterone and steroidal-core structure of vecuronium may explain the increased tolerance to vecuronium in this patient.