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Related Experiment Videos

Calciotropic hormones and bone markers in the elderly

J C Gallagher1, H K Kinyamu, S E Fowler

  • 1Bone Metabolism Unit, Creighton University School of Medicine, Omaha, Nebraska 68131, USA.

Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
|April 3, 1998
PubMed
Summary

Elderly Caucasians in North America show age-related increases in bone turnover. Higher parathyroid hormone (PTH) and bone markers in women suggest sex-based differences in bone metabolism, influenced by vitamin D status.

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Area of Science:

  • Gerontology
  • Endocrinology
  • Bone Metabolism

Background:

  • Limited data exists on calciotropic hormones and bone markers in North American elderly.
  • Age-related changes in bone health are crucial for this demographic.

Purpose of the Study:

  • To investigate changes in parathyroid hormone (PTH), serum 25-hydroxyvitamin D (25(OH)D), and bone markers in elderly Caucasians.
  • To compare these markers between elderly men and women.

Main Methods:

  • Measured serum PTH, 25(OH)D, osteocalcin, and urine N-telopeptide in 735 Caucasian subjects (aged 65-87).
  • Analyzed data for age-related trends and sex differences, adjusting for covariates.

Main Results:

  • Serum osteocalcin and urine N-telopeptide increased with age in men; osteocalcin increased with age in women.

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  • Women had higher mean PTH, osteocalcin, and urine N-telopeptide than men.
  • Men had higher mean 25(OH)D and urine calcium than women.
  • Vitamin D deficiency (25(OH)D < 12 ng/ml) was uncommon (3.3% in females, 0.4% in males).
  • PTH correlated with osteocalcin and inversely with 25(OH)D.

    • Conclusions:

    • Increased PTH in the elderly is primarily linked to vitamin D status rather than declining renal function.
    • Elderly women exhibit higher bone remodeling markers than elderly men.
    • Bone metabolism in the elderly is influenced by age, sex, and vitamin D levels.