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Localization of TGF-beta and its receptors in the kidney
1Second Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan. tando@med.kyushu-u.ac.jp
Mineral and Electrolyte Metabolism
|April 3, 1998
Abstract:
This paper reviews the expression and localization of proteins of the TGF-beta system in the kidney, i.e. TGF-beta isoforms, latent TGF-beta binding protein, and receptors. There is heterogeneity of TGF-beta isoforms, binding proteins and receptors. TGF-betas are more evenly distributed among different segments of the nephron than TGF-beta receptors, and are expressed by almost all cell types in the kidney. The spatial distribution of TGF-beta and its signaling receptor may help to better understand the biologic function of TGF-beta in the kidney.