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Updated: Aug 6, 2026

Identification of OTX1 and OTX2 As Two Possible Molecular Markers for Sinonasal Carcinomas and Olfactory Neuroblastomas
Published on: February 28, 2019
Prolonged survival in a patient with sinonasal teratocarcinosarcoma with cranial extension. Case report
S Terasaka1, M B Medary, D M Whiting
1Department of Neurosurgery, Allegheny University of the Health Sciences, Pittsburgh, Pennsylvania 15212-4746, USA.
Abstract:
Sinonasal teratocarcinosarcoma is a rare malignant neoplasm characterized by the combined histological features of carcinosarcoma and teratoma. The primary symptoms of this tumor are usually nasal obstruction and epistaxis, and a nasal cavity mass is the most common clinical finding. The authors describe an exceptionally rare case in which the patient presented with massive intracranial extension and exhibited confusion as an initial symptom. He subsequently underwent combined radical surgery and radiation therapy and has remained free of disease for 31 months. The surgical approach to the lesion, histological features, and clinical course are detailed.

