Related Experiment Videos
Diffuse craniospinal seeding from a benign fourth ventricle choroid plexus papilloma. Case report
R Leblanc1, S Bekhor, D Melanson
1Department of Neurology and Neurosurgery, Montreal Neurological Hospital, McGill University, Quebec, Canada.
Journal of Neurosurgery
|April 3, 1998
Summary
A benign choroid plexus papilloma in the fourth ventricle caused widespread metastasis to the brain and spinal cord. This rare case highlights the potential for benign tumors to spread extensively.
Area of Science:
- Neuro-oncology
- Pathology
- Neurosurgery
Background:
- Choroid plexus papillomas (CPPs) are typically benign tumors of the central nervous system.
- Metastasis from CPPs is rare and usually associated with malignant variants.
- Extensive leptomeningeal metastasis from a histologically benign CPP is exceptionally uncommon.
Observation:
- A 19-year-old woman presented with symptoms of increased intracranial pressure and ataxia.
- MRI revealed a large, enhancing tumor in the fourth ventricle causing obstructive hydrocephalus.
- Numerous cystic lesions were observed throughout the craniospinal leptomeninges.
Findings:
- Histopathological examination confirmed a benign choroid plexus papilloma of the fourth ventricle.
- Leptomeningeal lesions were identified as choroid plexus cysts.
- The benign tumor demonstrated diffuse, extensive leptomeningeal spread.
Implications:
- This case challenges the traditional understanding of benign choroid plexus papilloma behavior.
- It expands the differential diagnosis for posterior fossa tumors with subarachnoid dissemination.
- Further research into the biological potential of benign CPPs is warranted.