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Updated: Aug 14, 2026

Selective Tracing of Auditory Fibers in the Avian Embryonic Vestibulocochlear Nerve
Published on: March 18, 2013
ARIA is heavily expressed in rat peripheral auditory and vestibular ganglia
1Boys Town National Research Hospital, Omaha, NE 68131, USA. morley@boystown.org
Abstract:
The ARIA (acetylcholine receptor inducing activity) polypeptide is a member of the neuregulin gene family. It was originally purified on the basis of its ability to induce skeletal muscle nicotinic acetylcholine receptors (nAChRs). ARIA mRNA is expressed in ventral horn motor neurons and brain cholinergic neurons. We report here that ARIA mRNA is heavily expressed in the embryonic, developing, and adult peripheral auditory and vestibular ganglia, the spiral ganglion and Scarpa's ganglion. Neither ganglion is cholinergic, but both express mRNAs for nicotinic and muscarinic receptors. The expression of ARIA in these ganglia may be related to the regulation of cholinergic receptors or a more general role for ARIA in growth and development.
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