Phosphoinositide metabolism and Ca2+ oscillation
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Updated: Aug 11, 2026

Single-molecule Super-resolution Imaging of Phosphatidylinositol 4,5-bisphosphate in the Plasma Membrane with Novel Fluorescent Probes
Published on: October 15, 2016
1Department of Biological and Medical Chemistry, School of Basic Medicine, Lomonosov Moscow State University, Russia.
Abstract:
The main pathways of hydrolysis and synthesis of phosphoinositides, metabolism of inositol phosphates and their role in animal and human cells are reviewed. Mechanisms of regulation of phospholipase C and other key enzymes of phosphoinositide metabolism by hormones and growth factors are discussed. The mechanisms of regulation of metabolism and cellular activity by second messengers formed during activation of phosphoinositide hydrolysis are considered. Special attention is given to the regulation of cytoplasmic Ca2+ level by inositol phosphates. The review summarizes data on formation and possible biological role of inositol phosphates and phosphoinositides containing phosphate at position 3. The role of phosphoinositides in the interaction of cellular membranes with proteins of the cytoskeleton is considered.
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