Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hypertriglyceridemia as a cardiovascular risk factor

M A Austin1, J E Hokanson, K L Edwards

  • 1Department of Epidemiology, School of Public Health and Community Medicine, University of Washington, Seattle 98195-7236, USA.

The American Journal of Cardiology
|April 4, 1998
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Electronic health record reveals community-level cardiometabolic health benefits associated with 10 years of community-based participatory research.

Public health·2024
Same author

Oxford knee score 1 year after TKR for osteoarthritis with reference to a normative population: What can patients expect?

Osteoarthritis and cartilage open·2022
Same author

Pulmonary Arterial Pruning and Longitudinal Change in Percent Emphysema and Lung Function: The Genetic Epidemiology of COPD Study.

Chest·2021
Same author

Prospective analysis of health-related quality of life after surgery for spinal metastases.

European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·2020
Same author

Does surgical site infection influence neurological outcome and survival in patients undergoing surgery for metastatic spinal cord compression?

European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·2018
Same author

Genome-wide association study across European and African American ancestries identifies a SNP in DNMT3B contributing to nicotine dependence.

Molecular psychiatry·2017
Same journal

Real-World Effectiveness and Tolerability of Sacubitril/Valsartan in Octogenarian Patients With Heart Failure: Results From the PARACHUTER Study.

The American journal of cardiology·2026
Same journal

ECG-Guided Conduction Pathways as a Lever to Shorten Post-TAVI Hospitalization.

The American journal of cardiology·2026
Same journal

Cystatin-C versus creatinine and kidney function in heart failure with preserved ejection fraction: a SOGALDI-PEF analysis.

The American journal of cardiology·2026
Same journal

Balloon-expandable versus Self-expanding Valves in Patients with Small Aortic Annuli Undergoing Transcatheter Aortic Valve Replacement.

The American journal of cardiology·2026
Same journal

Drug-Coated Balloons versus Drug-Eluting Stents following Coronary Atherectomy in Severely Calcified Lesions: A Systematic Review and Meta-Analysis.

The American journal of cardiology·2026
Same journal

Prehospital Statin Therapy and Outcomes in ST-Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention.

The American journal of cardiology·2026
See all related articles

Elevated plasma triglyceride levels significantly increase cardiovascular disease risk in both men and women. This risk remains even after adjusting for other common risk factors, highlighting triglycerides

Area of Science:

  • Cardiovascular Epidemiology
  • Metabolic Syndrome Research
  • Clinical Biochemistry

Background:

  • Plasma triglyceride levels are a key lipid parameter.
  • Cardiovascular disease (CVD) remains a leading cause of mortality worldwide.
  • The independent role of triglycerides in CVD risk requires further elucidation.

Purpose of the Study:

  • To quantify the association between plasma triglyceride levels and incident cardiovascular disease.
  • To assess the impact of triglycerides on CVD risk in both men and women.
  • To evaluate the persistence of triglyceride-related risk after adjusting for other risk factors.

Main Methods:

  • Meta-analysis of 17 population-based prospective studies.
  • Inclusion of studies with Caucasian men and women and documented cardiovascular events.

Related Experiment Videos

  • Calculation of univariate and adjusted relative risks (RR) for cardiovascular disease per 1-mmol/L increase in triglycerides.

    • Main Results:

    • A 1-mmol/L increase in triglycerides was associated with a 32% increased CVD risk in men (RR: 1.32) and a 76% increased risk in women (RR: 1.76).
    • Adjusting for high-density lipoprotein cholesterol and other factors reduced but did not eliminate the risk (14% in men, 37% in women).
    • Recent studies confirm triglyceride and LDL particle size as predictors of coronary artery disease.

    Conclusions:

    • Plasma triglyceride levels are a significant, independent risk factor for cardiovascular disease.
    • Elevated triglycerides contribute substantially to cardiovascular risk in both genders.
    • Monitoring and managing triglyceride levels are crucial for cardiovascular disease prevention strategies.