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Interferon beta normalizes suppressor cell function in dysimmune neuropathies
Giovanna De Luca1, Alessandra Lugaresi1, Carla Iarlori1
1Center for Neuromuscular Diseases, Department of Oncology and Neurosciences of the University of Chieti, Policlinico Clinicizzato `Colle Dell'Ara', I-66013 Chieti, Italy.
Abstract:
We found a defective suppressor cell function in vitro both in idiopathic chronic inflammatory demyelinating polyneuropathy and in paraproteinemic neuropathy with antibodies to sulfated glucuronyl paragloboside. In the presence of interferon beta, suppressor cell function was normalized. Our results suggest that a decreased suppressor cell function plays a pathogenetic role in dysimmune neuropathies. Interferon beta might represent an adjunctive therapy in CIDP both acting on a defective blood-nerve barrier and normalizing an otherwise defective suppressor cell function.