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Updated: Aug 6, 2026

Assessing Endothelial Vasodilator Function with the Endo-PAT 2000
Published on: October 15, 2010
Homocysteinemia and endothelial damage after methionine load
J Hladovec1, Z Sommerová, A Písaríková
14th Medical Clinic, Medical Faculty, Charles University, Prague, Czech Republic.
Abstract:
Homocysteinemia increased significantly after a methionine load of 50 mg/kg in patients with peripheral artery occlusive disease but this load was insufficient to increase circulating endothelial cell count as a marker of endothelial damage. Only after an increased load of 100 mg/kg methionine circulating endothelial cells also increased markedly confirming the results of a previous experimental study. These data indicate a threshold concentration of homocysteine in blood necessary to induce endothelial lesions.
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