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The human obesity gene map: the 1997 update

Y C Chagnon1, L Pérusse, C Bouchard

  • 1Physical Activity Sciences Laboratory, Laval University, Ste-Foy, Québec, Canada.

Obesity Research
|April 4, 1998
PubMed
Summary

This study updates the human obesity gene map, identifying numerous obesity-related genetic loci across most human chromosomes. It synthesizes evidence from various genetic studies to pinpoint key genes contributing to obesity.

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Area of Science:

  • Genetics
  • Human Genomics
  • Obesity Research

Background:

  • Obesity is a complex multifactorial condition with a significant genetic component.
  • Understanding the genetic basis of obesity is crucial for developing effective interventions.
  • Previous gene mapping efforts have identified numerous loci associated with obesity.

Purpose of the Study:

  • To present an updated comprehensive map of human obesity genes.
  • To consolidate evidence from diverse genetic studies up to October 1997.
  • To identify chromosomal regions significantly associated with obesity.

Main Methods:

  • Review of evidence from Mendelian disorders with obesity phenotypes.
  • Analysis of rodent models with single-gene mutations.
  • Integration of quantitative trait loci (QTL) from human genome scans and animal crossbreeding.
  • Inclusion of association, case-control, and linkage studies.
  • Conversion of animal loci to human syntenic locations.

Main Results:

  • All human chromosomes except Y harbor obesity-related genetic loci.
  • Specific chromosomes (1, 2, 6, 8, 11, 20) show multiple loci on both arms.
  • Several chromosome arms (e.g., 3p, 4q, 5q) also contain obesity-associated loci.
  • Negative association and linkage findings were also cataloged.

Conclusions:

  • The human genome contains a substantial number of genetic loci influencing obesity.
  • This updated gene map provides a valuable resource for further obesity research.
  • Continued genetic investigation is essential for a deeper understanding of obesity etiology.

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