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Related Experiment Videos

Sentinel node biopsy in breast cancer

J M Barnwell1, M A Arredondo, D Kollmorgen

  • 1Division of Surgical Oncology, Roswell Park Cancer Institute, State University of New York at Buffalo, 14263, USA.

Annals of Surgical Oncology
|April 4, 1998
PubMed
Summary
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Sentinel lymph node biopsy (SNB) accurately identifies breast cancer metastasis. A negative SNB result may allow women to avoid axillary lymph node dissection (ALND).

Area of Science:

  • Oncology
  • Surgical Pathology

Background:

  • Sentinel lymph node biopsy (SNB) is a potential alternative to axillary lymph node dissection (ALND) for staging breast cancer.
  • Accurate axillary staging is crucial for effective breast cancer treatment.

Purpose of the Study:

  • To evaluate the success and accuracy of axillary SNB using isosulfan blue (ISB) and technetium-99 sulfur colloid (TSC).
  • To compare SNB findings with axillary lymph node dissection (ALND) results in breast cancer patients.

Main Methods:

  • Forty-two women with T1 or T2 breast cancer underwent SNB followed by ALND.
  • A mixture of ISB and TSC was injected prior to surgery for SLN identification.
  • SLN identification utilized a gamma detector and blue dye visualization.

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Main Results:

  • An axillary sentinel lymph node was identified in 90% of cases.
  • The SLN accurately predicted axillary metastases, with a 100% negative predictive value.
  • Previous excisional biopsy did not affect SLN localization or predictive value.

Conclusions:

  • A negative sentinel lymph node biopsy may obviate the need for axillary lymph node dissection in select breast cancer patients.
  • Further validation in larger studies is warranted to confirm these findings.