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Related Experiment Videos

Carbohydrate metabolism in lichen planus

N J Lowe, A G Cudworth, S A Clough

    The British Journal of Dermatology
    |July 1, 1976
    PubMed
    Summary

    A significant percentage of patients with oral lichen planus exhibit abnormal glucose tolerance, suggesting a link between this skin condition and diabetes. This finding highlights the importance of screening for glucose intolerance in affected individuals.

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    Area of Science:

    • Dermatology
    • Endocrinology
    • Metabolic Disorders

    Background:

    • Oral lichen planus is a chronic inflammatory condition affecting oral mucosa.
    • A potential association between oral lichen planus and metabolic disturbances like diabetes mellitus is being investigated.

    Purpose of the Study:

    • To investigate the prevalence of glucose intolerance in patients diagnosed with active oral lichen planus.
    • To explore the relationship between oral lichen planus and abnormal glucose metabolism, particularly in individuals without a family history of diabetes.

    Main Methods:

    • A cohort of forty patients with active oral lichen planus and no family history of diabetes was recruited.
    • Oral glucose tolerance tests were performed to assess glucose metabolism.
    • Insulin response patterns were analyzed.
    • Association between glucose intolerance and clinical characteristics of oral lichen planus was examined.

    Main Results:

    • 42% of patients with oral lichen planus demonstrated unequivocally abnormal oral glucose tolerance.
    • The observed insulin response patterns resembled those seen in mild maturity-onset diabetes.
    • No correlation was found between glucose intolerance and the duration or type of oral lichen planus lesions.
    • Islet-cell antibodies were not detected in patients with glucose intolerance.

    Conclusions:

    • Active oral lichen planus may be associated with a high prevalence of undiagnosed glucose intolerance.
    • The findings suggest a potential link between oral lichen planus and impaired glucose metabolism, warranting further investigation.
    • Screening for glucose intolerance should be considered in patients with oral lichen planus, irrespective of lesion characteristics.

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