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[Mechanisms of cell death in Alzheimer's disease]
M R Luquin1, E Martínez-Vila, L Saldise
1Departamento de Neurología y Neurocirugía, Clínica Universitaria, Facultad de Medicina, Universidad de Navarra.
Revista De Medicina De La Universidad De Navarra
|January 1, 1997
Abstract:
Molecular mechanisms involved in neuronal degeneration in Alzheimer's disease remain still unknown. A toxic effect induced by beta amyloid, oxidative stress, excitotoxicity and alterations in signal transduction mechanisms are the main factors linked to neuronal death. In addition, it has been suggested that apoptosis may also participate as a part of the cascade of events resulting in neurodegeneration.