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Neonatal hypoperistalsis associated with perinatal zidovudine administration
M I Neuman1, Z Molle, E L Handelsman
1Department of Gastroenterology and Nutrition, Children's Medical Center at Brooklyn, USA.
Objective:
This paper presents the cases of two infants exposed to perinatal zidovudine in whom hypoperistalsis and intestinal pseudoobstruction developed.
Study Design:
Clinical case reports were prepared of two infants born to women infected with human immunodeficiency virus who were treated with perinatal zidovudine at a single inner-city medical school.
Results:
None of the previously described causes for this rare condition contributed to the symptoms in these two infants. In addition, the symptoms resolved shortly after discontinuation of zidovudine administration.
Conclusions:
Although a strict cause-and-effect relationship between the medication and the impairment in intestinal peristalsis was not proved, awareness of this association should be helpful for physicians caring for infants exposed to perinatal zidovudine.