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Related Experiment Videos

Viscosity and retinal vein thrombosis

C P Ring, T C Pearson, M D Sanders

    The British Journal of Ophthalmology
    |June 1, 1976
    PubMed
    Summary

    Elevated blood viscosity and hematocrit in retinal vein occlusion patients correlate with capillary non-perfusion. These factors may contribute to the development of retinal vein occlusion and its complications.

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    Area of Science:

    • Ophthalmology
    • Hematology
    • Vascular Biology

    Background:

    • Retinal vein occlusion (RVO) is a significant cause of vision loss.
    • Capillary non-perperfusion in RVO is linked to increased morbidity and neovascularization.
    • Understanding hemorheological factors in RVO is crucial for managing complications.

    Purpose of the Study:

    • To investigate the relationship between hemorheological parameters and capillary non-perfusion in RVO patients.
    • To explore the association of blood viscosity and hematological factors with RVO development and severity.
    • To identify potential biochemical markers associated with RVO complications.

    Main Methods:

    • Whole-blood and plasma viscosity, packed cell volume, and plasma fibrinogen levels were measured in 44 RVO patients.
    • Patients were categorized based on fluorescein angiography findings (large/small capillary non-perfusion, intact pattern).
    • Biochemical investigations were conducted, and results compared between patient subgroups and a control group (30 individuals).

    Main Results:

    • Significantly higher whole-blood viscosity, packed cell volume, and yield stress were observed in RVO patients with capillary non-perfusion.
    • The entire RVO group exhibited higher whole-blood viscosity, plasma viscosity, and plasma fibrinogen levels compared to controls.
    • Biochemical analyses indicated a strong association with arterial disease and a higher incidence of abnormalities in patients with capillary non-perfusion.

    Conclusions:

    • Increased whole-blood viscosity and packed cell volume are associated with capillary non-perfusion in RVO, suggesting an etiological role.
    • Elevated hemorheological parameters and plasma fibrinogen may contribute to RVO development.
    • Biochemical abnormalities are more prevalent in RVO patients with capillary non-perfusion, linking to arterial disease.

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