Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Immunotoxicity of beryllium]

T Sakaguchi1, S Sakaguchi, Y Kudo

  • 1Department of Life Science, Kawamura College, Tokyo, Japan.

Nihon Eiseigaku Zasshi. Japanese Journal of Hygiene
|April 7, 1998
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Identification of a universal three-body s-wave resonance in <sup>10</sup>He.

Nature communications·2026
Same author

Non-invasive detection of regulatory T cells with Raman spectroscopy.

Scientific reports·2024
Same author

Mass, Spectroscopy, and Two-Neutron Decay of ^{16}Be.

Physical review letters·2024
Same author

Observation of the Exotic 0_{2}^{+} Cluster State in ^{8}He.

Physical review letters·2024
Same author

Comparing the MiniBox™ and the Chestac-8900<sup>®</sup> for pulmonary function testing.

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease·2023
Same author

Multiple Mechanisms in Proton-Induced Nucleon Removal at ∼100  MeV/Nucleon.

Physical review letters·2023
Same journal

[Associations among Research Funding Status, Marital Status, Number of Children, and Psychological Well-Being of Social Medicine Researchers: A Gender-Based Analysis from Web Survey of Medical Researchers].

Nihon eiseigaku zasshi. Japanese journal of hygiene·2026
Same journal

[Preventing Bathing-Related Accidents without Overemphasizing "Heat Shock": toward Prevention Strategies Centered on Heat-Related Illness].

Nihon eiseigaku zasshi. Japanese journal of hygiene·2026
Same journal

[Evidence and Dissemination of Lively 100-Year-Old Exercise: Promoting Community-based Initiatives for Fall Prevention Among Community-dwelling Older Adults].

Nihon eiseigaku zasshi. Japanese journal of hygiene·2026
Same journal

[Associations between Self-reported Symptoms, Quality of Life, and Work Productivity Loss among Japanese Workers: A Cross-sectional Analysis of a Large-scale Questionnaire-based Person-reported Outcomes Database (PRO-DB)].

Nihon eiseigaku zasshi. Japanese journal of hygiene·2026
Same journal

[Individual Differences in the Impact of Habitual Alcohol Drinking on Blood Pressure].

Nihon eiseigaku zasshi. Japanese journal of hygiene·2026
Same journal

[Association between Social Relationships and Domain-specific Cognitive Functions among Community-dwelling Older Adults: The Wakayama Study].

Nihon eiseigaku zasshi. Japanese journal of hygiene·2026
See all related articles

Beryllium exposure impacts cell-mediated immunity and immunoglobulin levels in mice and humans. Beryllium exposure also suppressed hematopoietic function and decreased serum complement, suggesting health risks associated with this metal.

Area of Science:

  • Immunology
  • Toxicology
  • Hematology

Context:

  • Beryllium (Be) exposure is a concern in occupational settings, particularly in copper-beryllium casting factories.
  • Cell-mediated immunity, B cell function, and coagulation pathways are potentially affected by beryllium exposure.
  • Hematopoietic function and its regulation during pregnancy can be influenced by environmental factors like beryllium.

Purpose:

  • To investigate the multifaceted effects of beryllium exposure on immune function, coagulation, and hematopoietic processes.
  • To examine the correlation between beryllium exposure and specific immunological markers in both animal models and human workers.
  • To assess the impact of beryllium on pregnancy-related hematopoietic changes.

Summary:

  • Beryllium exposure was found to affect cell-mediated immunity, increase immunoglobulin levels, and decrease serum complement titers in mice and humans.

Related Experiment Videos

  • A negative correlation was observed between complement titers and coagulation factors (prothrombin time, factor VII) in beryllium-exposed mice.
  • Beryllium exposure suppressed the expected pregnancy-induced increase in hematopoietic function, indicated by altered delta-aminolevulinic acid dehydratase and porphobilinogen deaminase activities.

    • Impact:

    • Findings highlight the potential health risks of beryllium exposure, including immune system dysregulation and suppressed hematopoietic function.
    • Identifies exposure and genetic predisposition as key risk factors for beryllium-induced diseases.
    • Emphasizes the need for reduced exposure, preventive education, and regular health screenings for beryllium workers.