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Corneal changes in patients treated with clofazimine
The British Journal of Ophthalmology
|July 1, 1976
Summary
Fine brownish lines, a potential side effect of clofazimine, were observed in psoriatic patients. These reversible changes did not affect vision and resembled chloroquine keratopathy.
Area of Science:
- Ophthalmology
- Dermatology
- Pharmacology
Background:
- Psoriasis is a chronic inflammatory skin condition.
- Clofazimine is a medication used to treat leprosy and other conditions.
- Ocular side effects of medications require careful monitoring.
Observation:
- Two of 19 patients with psoriasis developed fine, brownish lines in their corneas.
- These corneal changes were noted during treatment with clofazimine.
- The observed lines were morphologically similar to chloroquine keratopathy.
Findings:
- The corneal changes associated with clofazimine were reversible.
- No visual impairment or functional disturbance was reported in affected patients.
- The incidence of these ocular findings was approximately 10.5% in the studied group.
Implications:
- This suggests a potential, reversible ocular side effect of clofazimine therapy.
- Ophthalmologists and dermatologists should be aware of these potential corneal changes.
- Monitoring for visual disturbances may be warranted in patients on long-term clofazimine treatment.