[Biological aging and apoptosis--mechanism in cardiovascular disease?]

Smoking, lipid disorders, hypertension and diabetes are well known risk factors for cardiovascular disease. Many individuals are characterised by a genetically determined predisposition and moreover, psychosocial factors and an inappropriate life style may exert adverse effects on biological variables. Evidence exists which suggests that in such cases various ageing processes may be accelerated. Studies of apoptosis regulation can yield improved understanding of such phenomena as atherosclerotic plaque rupture and such structural cardiovascular changes as left ventricular hypertrophy. A possible clinical result of such events may be manifest myocardial infarction, followed by heart failure and a predisposition to arrhythmia. The recent identification of apopain, a proteolytic enzyme associated with apoptosis, may eventually enable drugs to be developed for the regulation of apoptosis.