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Increased leptin expression in mice with bacterial peritonitis is partially regulated by tumor necrosis factor alpha
A K Moshyedi1, M D Josephs, E K Abdalla
1Department of Surgery, University of Florida College of Medicine, Gainesville 32610, USA.
Infection and Immunity
|April 7, 1998
Abstract:
Plasma leptin and ob gene mRNA levels were increased in mice following bacterial peritonitis, and blocking an endogenous tumor necrosis factor alpha (TNF-alpha) response blunted the increase. However, plasma leptin concentrations did not correlate with the associated anorexia. We conclude that leptin expression is under partial regulatory control of TNF-alpha in peritonitis, but the anorexia is not dependent on increased leptin production.