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An alternative method to normalize clinical FDG studies

A Sandell1, T Ohlsson, K Erlandsson

  • 1Department of Radiation Physics, University Hospital, Lund, Sweden.

Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
|April 7, 1998
PubMed
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A new method uses erythrocytes to determine the integrated input function for quantitative [18F]fluorodeoxyglucose (FDG) studies. This simplified approach offers sufficient accuracy for clinical PET scans and is suitable for pediatric research.

Area of Science:

  • Nuclear Medicine
  • Biochemistry

Background:

  • Quantitative analysis in positron emission tomography (PET) requires accurate determination of the integrated input function.
  • The traditional method involves multiple blood samples, which can be invasive and time-consuming.

Purpose of the Study:

  • To develop a simplified and accurate method for determining the integrated input function using erythrocytes as reference tissue.
  • To validate this new method against traditional approaches.

Main Methods:

  • Erythrocytes were used as a reference tissue to measure the integrated input function after [18F]fluorodeoxyglucose (FDG) injection.
  • FDG-6-phosphate in erythrocytes was quantified after washing to remove free FDG.
  • In vitro incubation corrected for inter- and intraindividual metabolic differences in erythrocytes.

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Main Results:

  • The erythrocyte-based method provides the integrated input function with an accuracy better than +/-8%.
  • Results correlated well with the integrated input function derived from multiple venous blood samples.

Conclusions:

  • Erythrocytes serve as a suitable reference tissue for determining the integrated input function in quantitative FDG autoradiography.
  • This method is accurate enough for clinical PET studies and practical for pediatric populations.
  • The method also supports simplified graphical Patlak analysis with two samples.