Hypertrophic lichen planus mimicking squamous cell carcinoma

Area of Science:

• Dermatology
• Pathology

Background:

• Hypertrophic lichen planus is a chronic inflammatory skin condition.
• It can present with hyperkeratotic lesions that may clinically resemble other dermatoses.

Observation:

• An elderly female presented with hyperkeratotic nodules on her shin, initially suspected as squamous cell carcinoma.
• Clinical and initial histological examination supported this diagnosis.

Findings:

• Review of the biopsy revealed hypertrophic lichen planus with pseudoepitheliomatous hyperplasia.
• Typical lichen planus was also observed in the oral mucosa, nails, and other skin areas.

Implications:

• This case highlights the diagnostic challenge posed by hypertrophic lichen planus.
• Accurate histological interpretation is crucial to differentiate it from squamous cell carcinoma, ensuring appropriate patient management.